Follistatin-344: A Comprehensive Research Guide
Follistatin-344 is one of the most studied peptides in muscle biology and metabolic research. As a potent myostatin inhibitor, it has attracted significant interest from researchers investigating muscle growth, metabolic regulation, and regenerative medicine.
What is Follistatin-344?
Follistatin-344 is a naturally occurring glycoprotein encoded by the FST gene. It functions primarily as an activin-binding protein and a myostatin inhibitor research tool. The “344” refers to the 344-amino acid isoform, which is the most commonly used variant in research settings.
Key Biological Functions
- Myostatin Inhibition: Binds to and neutralizes myostatin, a negative regulator of muscle growth
- Activin Binding: Inhibits activin A and activin B signaling pathways
- BMP Modulation: Interacts with bone morphogenetic proteins
- FSH Regulation: Modulates follicle-stimulating hormone in reproductive research
Research Applications
Muscle Biology
The primary research application of follistatin-344 research is in understanding muscle growth and atrophy mechanisms. By inhibiting myostatin, follistatin-344 allows researchers to study muscle hypertrophy pathways in preclinical models.
Metabolic Research
Studies have explored follistatin’s role in metabolic regulation, including glucose metabolism, fat distribution, and energy homeostasis. Research suggests connections between follistatin signaling and metabolic syndrome markers.
Reproductive Biology
Follistatin plays a key role in reproductive physiology by modulating activin and FSH. Researchers use follistatin-344 to study fertility mechanisms and reproductive endocrinology.
Fibrosis Research
Emerging studies investigate follistatin’s potential role in modulating fibrotic pathways, particularly in liver, cardiac, and pulmonary fibrosis models.
Handling and Storage
- Form: Supplied as lyophilized powder
- Storage: -20°C for long-term; 2–8°C for short-term use
- Reconstitution: Use sterile water or bacteriostatic water; add solvent gently along vial wall
- Stability: Reconstituted solutions stable at 2–8°C for up to 14 days; aliquot for longer storage
- Purity: Research-grade requires ≥98% by HPLC
Quality Specifications to Look For
- HPLC purity ≥98%
- Mass spectrometry confirmation of molecular weight
- Endotoxin testing for in-vivo research applications
- SDS-PAGE verification of protein integrity
- Amino acid analysis confirming sequence
Source Follistatin-344 from Aarise Healthcare
Aarise Healthcare supplies research-grade follistatin peptide at 99%+ purity with comprehensive COA documentation including HPLC, mass spectrometry, and endotoxin testing results.
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